ABSTRACT
To observe the effects of metformin HC1 on the carbohydrate metabolism in polycystic ovary syndrome a clinical trial was carried out on fifty infertile females having polycystic ovary syndrome with ages between 20-40 years. They were enrolled from the infertility clinic of a private hospital in Karachi and were given tablet metformin HC1 500 mg thrice daily for a period of three months. Fasting serum glucose [FSG] and fasting serum insulin [FSI] were done twice during the study period [at day zero and day ninety] to assess the effects on the carbohydrate metabolism. Significant reduction was found in both the FSG and FSI levels at day ninety with P=0.001. It is concluded that metformin has produced beneficial effects on the carbohydrate metabolism in patients having polycystic ovary syndrome. This is because of increase peripheral uptake and utilization of glucose being done by metformin which in turn increases the insulin sensitivity and reduces the insulin resistance in these patients
ABSTRACT
Neurotoxicants and environmental pollutants cause neuronal damage and may damage myelin sheath. Since Methyl cobalamine [B12] has effect on myelin sheath formation it was hypothesized that B12 administration in case of nerve damage by some neurotoxicants may be protected or corrected by B12 administration. [Braun, 1977 and Braun, 1980]. For generations physicians have recommended B-vitamins especially B12 for neuropsychiatric symptoms. In present study neuroprotective role of B12 is assessed. Present work was planned to evaluate the therapeutic or prophylactic role of B12 in nerve damage by neurotoxicant i.e. glutamic acid. Present study revealed no significant neuroprotection or defensive regimen offered by B12 for neurotoxic damage. Glutamic acid is probably affecting neurons or dentritis sparing myelin sheath. Neuroprotection expected by B12 may be applied only to myelin sheath